报告人：田中正人 教授

报告时间：7月13日（周五）下午16:00-17:30

报告地点：动医动科楼401会议室

联系人：陈耀星 教授

报告人简介：

    田中正人，医师，教授，博士生导师，东京药科大学免疫调节学系主任

1988年 毕业于东京医科齿科大学

1995年 东京医科齿科大学取得医学博士学位

1997-2002年 先后在大阪大学任助教、副教授

2002-2011年 在日本理化学研究所任实验室主任

2011年至今  在东京药科大学任主任教授。

     田中教授长期从事天然免疫细胞在免疫调节与免疫耐受的作用机制及自身免疫炎症与肿瘤等相关疾病机制的研究，以第一/通讯作者在Science、Nature、 Nat Med、Cell、Immunity、J Exp Med、J Clin Invest、PNAS等杂志发表论文多篇，他引9000余次。主持日本文部科学省课题16项，总经费约3500万人民币。

代表性论文：

1. Karasawa K, Tanaka M. Vascular-Resident CD169-Positive Monocytes and Macrophages Control Neutrophil Accumulation in the Kidney with Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology. JASN, 2015, 26(4):896-906.

2. Asano K, Tanaka M. Intestinal CD169(+) macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes. Nat Commun, 2015, 6:7802.

3. Asano, K., A. Nabeyama, Y. Miyake, Tanaka M. CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens. Immunity, 2011, 34:85-95.

4. Nabeyama A, Kurita A, Asano K, Tanaka M. xCT deficiency accelerates chemically induced tumorigenesis.  PNAS, 2010, 107:6436-6441.

5. Qiu CH, Miyake Y, Tanaka M. Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens. J Immunol, 2009, 182:4127-4136.

6. Miyake Y, Kaiseand H, Tanaka M. Protective Role of Macrophages in Noninflammatory Lung Injury Caused by Selective Ablation of Alveolar Epithelial Type II Cells. J Immunol, 2007, 178:5001-5009.

7. Miyake Y, Asano K, Tanaka M. Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest, 2007, 117:2268-2278.

8. Asano K, Miwa M, Miwa K, Nagata S, Tanaka M. Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice. J Exp Med, 2004, 200:459-467.

9. Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M, Uchiyama Y, Nagata S. Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice. Science, 304: 1147-1150, 2004.

10. Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature, 2002, 417:182-187.

11. Tanaka, M., M.E. Fuentes, K. Yamaguchi, and D.V. Goeddel. 1999. Embryonic lethality, liver degeneration, and impaired NF-kappaB activation in IKK-beta-deficient mice. Immunity 10:421-429.

12. Tanaka M, Itai T, Adachi M, Nagata S. Downregulation of Fas ligand by shedding. NatMed, 1998, 4(1):31-6.

13. Tanaka M, Suda T, Yatomi T, Nakamura N, Nagata S. Lethal effect of recombinant human Fas ligand in mice pretreated with Propionibacterium acnes. J Immunol, 1997, 158(5):2303-9.

14. Tanaka M, Suda T, Haze K, Nakamura N, Sato K, Kimura F, Motoyoshi K, Mizuki M, Tagawa S, Ohga S,Hatake K, Drummond AH, Nagata S. Fas ligand in human serum.  Nat Med, 1996, 2(3):317-22.

15. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell, 1994, 76: 969-976.

16. Tanaka M, Suda T, Takahashi T, Nagata S. Expression of the functional soluble form of human fas ligand in activated lymphocytes. Embo J, 1995, 14: 1129-1135.

17. Kikuchi K, Iida M, Ikeda N, Tanaka M, Asano K. Macrophages Switch Their Phenotype by Regulating Maf Expression during Different Phases of Inflammation. J Immunol. 2018.

18. Asano K, Kikuchi K, Tanaka M. Immune regulation by CD169 macrophages. J Biochem. 2018.

欢迎老师和同学参加！